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5-Fluorouracil (5-FU), found in the treating intestinal tract and breast cancers, is converted intracellularly to 5-fluoro-2-deoxyuridine (5-FUdR) by thymidine phosphorylase and is consequently phosphorylated by thymidine kinase to 5-fluoro-2-dispose of (5-FdUMP). This energetic metabolite, combined with the diminished folate cofactor, 5,10-methylenetetrahydrofolate, types a comfortable inhibitory sophisticated with thymidylate synthase that obstructs cellular progress. The present research signifies that the ATP-centered multidrug weight necessary protein-5 (MRP5, ABCC5) confers effectiveness against 5-FU by transporting the monophosphate metabolites. MRP5- and vector-transfected individual embryonic renal (HEK) cells were utilized in these studies. In 3-evening cytotoxicity assays, MRP5-transfected tissues have been about 9-fold resistant to 5-FU and 6-thioguanine. Scientific studies with inside of-out membrane vesicles prepared from transfected cellular material demonstrated that MRP5 mediates ATP-centered transportation of 5 micromol/L [(3)M]5-FdUMP, [(3)They would]5-FUMP, [(3)L]eliminate, rather than [(3)They would]5-FUdR, or [(3)L]5-FU. The ATP-primarily based transportation of 5-FdUMP demonstrated saturation with raising concentrations and had a E(m) of 1.1 mmol/T and /(utmost) of 439 pmolPerminimum/milligram protein. Uptake of 250 micromol/M 5-FdUMP was restricted by dUMP, cyclic nucleotide, cyclic guanosine 3,5-monophosphate, amphiphilic anions for example probenecid, MK571, the phosphodiesterase inhibitors, trequinsin, zaprinast, and sildenafil, through the chloride channel blockers, 5-nitro-2-(3-phenylpropylamino)-benzoic chemical p and glybenclamide. Additionally, the five-FU drug sensitivity of HEK-MRP5 tissues was partially modulated to that in the HEK-vector by the existence of 40 micromol/T 5-nitro-2-(3-phenylpropylamino)-benzoic acid although not by 2 mmol/L probenecid. Therefore, MRP5 conveys the monophosphorylated metabolite of the nucleoside when MRP5 is overexpressed in intestinal tract and busts malignancies, it might help with 5-FU medication opposition.

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Family Dinners

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Chang’s Combo Platters

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Chang Bro’s Special Grills

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Chang Bro’s Special Grills

B.B.Q. Pork Chop Tender boneless pork chop marinated in Chang’s Special B.B.Q. sauce and served w/ house salad and rice. 8.95 Lemongrass Chicken Tender boneless chicken marinated in lemongrass sauce, and serve on top of rice noodle and house...

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Chef’s Lunch Special

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Chef’s Lunch Special

Served fried rice or steamed rice, and Egg Roll * Supreme Crispy Eggplant 6.50 Lemon Chicken 6.50 * Pepper Salt Chicken Wings 6.50 * Morango Delight 6.95 Triple Delight 5.95 * Malaysian Style Curry Chicken or Beef 5.95 * General Tso’s Chicken 6.95 Honey Sesame Chicken 6.95 Chef Delight 6.95 * Orange Chicken 6.95 * Curry Shrimp 6.95 Chang’s Honey Sesame Shrimp 7.25 * General Tso’s Shrimp 7.25 Crispy Walnut Shrimp 7.25 Lemongrass Chicken Tender...

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Lunch Combination Platter

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Lunch Combination Platter

Served with steamed rice or fried rice, and Egg Roll 1 Sweet and Sour Pork 5.95 2   Sweet and Sour Chicken 5.95 3 * Kung Pao Chicken 5.95 4   Chicken Cashew Nuts 5.95 5 Moo Goo Gai Pan 5.95 6 * Chicken Broccoli 5.95 7 * Chicken String Bean 5.95 8 Beef w/ Broccoli 5.95 9 * Beef in Hot Garlic Sauce 5.95 10 Beef w/ Mix Vegetables 5.95 11 Chicken w/ Mix Vegetables 5.95 12 * Chicken in Hot Garlic Sauce 5.95 13 * Double Cooked Pork 5.95 14 Barbecue Pork w/ Snow...

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Malaysian Style Curry Dishes

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Malaysian Style Curry Dishes

Dinner 咖 哩 牛 或 雞 * Curry Beef or Chicken 9.25 咖 哩 蝦 * Curry Shrimp or Scallop 10.50 咖 哩三 鮮 * Curry Triple...

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Egg Foo Young

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Egg Foo Young

Please select from one of the following meat: Chicken, Beef or Vegetables 8.50 Shrimp or...

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Moo Shi

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Moo Shi

(serve with four pancakes) 木 須 肉 Moo Shi Pork 8.50 木 須 雞 Moo Shi Chicken 8.50 木 須 牛 Moo Shi Beef 8.50 木 須 蝦 Moo Shi Shrimp 9.95 木 須 菜 Moo Shi...

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Fried Rice, Chow Mein, & Noodles

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Fried Rice, Chow Mein, & Noodles

Fried Rice Please select from one of the following meat: Chicken, Roast pork, vegetable or Beef 6.95 Spinach Fried Rice 6.95 Shrimp or Combination 7.75 Yang Chow Fried Rice 7.75 Chow MeinPlease select from one of the following meat: Chicken, Roast pork, vegetable or Beef 6.95 Shrimp or Combination 7.75 Noodles 星 洲 米 粉 Singapore Rice Noodle Sliced chicken, shrimp, sautéed w/bell peppers, onions, bean sprouts & egg strips in a light curry flavor. 8.50 馬...

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Vegetarian Corner

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Vegetarian Corner

素 什 錦 Mixed Vegetables in Brown Sauce 7.25 紅 燒 豆 腐 Braised Bean Curd 7.25 羅 漢 豆 腐 Fried Bean Curd w/ Combination Vegetables 7.25 麻 婆 豆 腐 * Bean Curd Szechwan Style 7.25 湖 南 豆 腐 * Bean Curd Hunan Style 7.25 干 扁 四 季 豆 * Szechwan String Bean 7.25 魚 香 芥 蘭 * Sautéed Broccoli in Hot Garlic Sauce 8.95 脆皮茄子 * Supreme Crispy Eggplant 8.50 95時菜 * Chang Bros’ Seasonal Green Please ask for availability. Choose from fresh Chinese...

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Pork

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Pork

甜 酸 肉 Sweet & Sour Pork 8.50 雪 豆 叉 燒 Barbecued Pork w/ Snow Peas 8.50 回 鍋 肉 * Double Cooked Pork 8.50 魚 香 肉 * Pork in Hot Garlic Sauce 8.50 蘆 筍 肉 Pork w/ Asparagus (seasonal) S.P. 椒鹽骨 Pepper Salt Pork...

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Poultry

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Poultry

甜 酸 雞 Sweet & Sour Chicken 8.50 芥 蘭 雞 Chicken Broccoli 8.50 蘑 菇 雞 片 Moo Goo Gai Pan 8.50 腰 果 雞 丁 Chicken Cashew Nuts 8.50 宮 保 雞 丁 * Kung Pao Chicken 8.50 什 錦 菜 雞 Chicken w/ Mixed Vegetable 8.50 Chicken Chop Suey 8.50 魚 香 雞 * Chicken in Hot Garlic Sauce 8.50 雪 豆 雞 Chicken w/ Snow Peas 8.50 * Basil Chicken 8.50 四 季 豆 雞 * Chicken w/ String Bean 8.50 檸檬雞 Lemon Chicken 8.50 豉 椒 雞 片 * Chicken in Black...

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Beef

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Beef

芥 蘭 牛 Beef w/ Broccoli 8.95 羅 漢 牛 Beef w/ mixed Vegetables 8.95 青 椒 牛 Pepper Steak 8.95 雪 豆 牛 Beef w/ Snow Peas 8.95 魚 香 牛 * Beef in Hot Garlic Sauce 8.95 腰 果 牛 Beef w/ Cashew Nuts 9.95 豉 椒 牛 * Beef in Black Bean Sauce 8.95 宮 保 牛 * Kung Pao Beef 9.95 蔥 爆 牛 * Mongolian Beef 9.95 蘆 筍 牛 Beef w/ Asparagus...

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Seafood

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Seafood

豉 椒 干 貝 或 蝦 * Shrimp or Scallop in Black Bean Sauce 10.95 魚 香 干 貝 或 蝦 * Shrimp or Scallop in Hot Garlic Sauce 10.50 宮 保 蝦 仁 * Kung Pao Shrimp 10.75 腰 果 蝦 Shrimp w/ Cashew Nuts 10.75 酸甜蝦 Sweet & Sour Shrimp 10.50 蝦 龍 糊 Shrimp in Lobster Sauce 10.50 宮 保 雙丁 * Morengo Delight Baby shrimps and diced chicken sautéed with ruby pepper, onion, peanut, celery, and string bean in a hot tasty plum sauce. 10.50 珊 瑚 蝦 * Coral ShrimpJumbo...

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Salads

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Salads

本 樓 沙 拉 House Special SaladMixed fresh greens w/House special sweet & sour dressing sprinkled w/sesame seeds. 3.95 雞 絲 沙 拉 Chicken SaladFresh vegetables, grilled chicken w/ light Thai fish...

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Hot Appetizers

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Hot Appetizers

寶 寶 盆 Po Po Platter (for two)Egg Rolls, Ribs, Cheese Wonton, Stick Beef, Chicken Wings, Shrimp Tempura 10.50 素 春 卷 Vegetable Spring Roll (2) 2.50 春     卷 Egg Rolls (2) 2.50 素 菜 餃 Vegetable Dumplings (6) 4.75 鍋 貼 Pork or Chicken Dumplings (Steamed or Pan Fried) (6) 4.75 炸 餛 飩 Crabmeat Cheese Fried Wonton (5) 4.95 紅 油 抄 手 * House Spicy Tangy Wonton (8) 3.75 炸雞翅 Fried Chicken Wings (6) 3.75 炸 大 蝦 Shrimp Tempura (4) 4.50 炸 魷...

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Soups

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Soups

Pt. Qt. 酸 辣 湯 * Hot & Sour Soup 2.75 5.25 蛋 花 湯 Egg Drop Soup 2.75 5.25 餛 飩 湯 Wonton Soup 2.75 5.25 什 錦 餛 飩 湯 Subgum Wonton Soup 6.25 wonton soup with shrimp, scallop, chicken and vegetables 玉 米 雞 茸 湯 Creamy Chicken Corn Soup 6.50 素 菜 豆 腐 湯 Tofu and Vegetables Soup 5.25 Seafood tofu soup 6.50 Noodles Soup Choice of Chicken, Beef, Pork – 7.95  Shrimp or Seafood –...

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